“Change your thoughts and you change your world.” — Norman Vincent Peale
Psychedelics have been used for centuries in indigenous healing traditions, yet only recently has Western medicine begun to embrace their therapeutic potential. Research dating back to the 1950s—and now experiencing a modern resurgence—suggests that psychedelics can offer profound benefits for mental health, particularly for treatment-resistant conditions like depression, PTSD, and anxiety.
But how do different psychedelics work, and which might be beneficial for mental health? Let’s explore the most well-researched options.
Ketamine: A Fast-Acting Mood Booster
Ketamine, a legal dissociative anesthetic, has been used in medical settings since the 1970s. When combined with psychotherapy, it has shown remarkable effectiveness in treating depression, with mood-enhancing effects appearing within hours. Unlike traditional antidepressants, ketamine doesn’t require daily dosing and has minimal side effects. It promotes neuroplasticity, helping the brain form new, healthier thought patterns—especially beneficial for those stuck in cycles of negative thinking.
Psilocybin: The “Magic” Behind Mushrooms
Psilocybin, found in psychedelic mushrooms, alters perception, emotions, and one’s sense of self. Many describe their experiences as deeply spiritual or life-changing, with studies ranking psilocybin journeys among the most meaningful experiences of people’s lives. Research shows its potential in treating depression, anxiety, addiction, and existential distress in terminally ill patients. A single dose can lead to lasting improvements in mood and perspective.
MDMA: Healing Through Connection
MDMA, commonly known as “ecstasy” or “molly,” is undergoing FDA clinical trials and may soon be approved for PTSD treatment. Unlike classic psychedelics, MDMA enhances feelings of love, connection, and emotional openness, making it a powerful tool for trauma processing. It helps clients revisit painful memories without fear, reducing PTSD symptoms like flashbacks and anxiety while fostering deep healing.
The Importance of Guided Psychedelic Therapy
Psychedelics aren’t magic pills—they work best when combined with professional therapeutic support. While they can bring up challenging emotions and memories, a trained psychedelic therapist ensures a safe, supportive space for healing and integration.
Explore Healing with Me
Monica Ramunda, founder of Rocky Mountain Counseling Services and co-founder of Wellness and Wisdom Journeys, specializes in curated wellness experiences.
Monica Ramunda is one of the US’s first Certified Psychedelic Assisted Therapist and offers women’s retreats. She is the owner of Sacred Healing Journeys and co-owner of Wellness and Wisdom Journeys. Please reach out at rockymtncounseling@gmail,.com.
